@article{Tra_Thu Ha_Cham_Tu Anh_Thao_Nga_Mai Huong_Cuong_2017, title={3D cytotoxic and histon deacetylase (HDAC) inhibitory activities of triterpenoids isolated from leaves of Viburnum sambucinum}, volume={55}, url={https://vjst.net/index.php/vjchem/article/view/2525-2321.2017-00533}, DOI={10.15625/2525-2321.2017-00533}, abstractNote={<p>The plant <em>Viburnum sambucinum </em>has been known under the local name “Vót dạng cơm cháy” belongs to <em>Viburnum</em> genus, a member of the Caprifoliaceae family. Many plants of <em>Viburnum genus are well known for their medicinal properties and are used in the folk medicine for the treatment of various diseases. A variety of structures have been reported from the plants of the genus,</em><em> </em>such as diterpenes, triterpenes, iridoids, sesquiterpenes, flavonoids, etc. In this study, we describe 3D cytotoxic and histone deacetylase (HDAC) inhibitory activities of two nordammarane triterpenoids hupehenol D (<strong>1</strong>) and 12<em>β</em>-hydoxy-3,15-dioxo-20,21,22-23,24,25,26,27-octanordammanrane (<strong>2) </strong>isolated from the leaves of <em>Viburnum sambucinum</em>. The result showed that (<strong>1</strong>) and (<strong>2</strong>) exhibited a strong activity against 3D models of LLC cell line with the IC<sub>50</sub> value ​​of 25.89 µM and 15.58 µM, respectively. Compound <strong>1</strong> weakly inhibited activity of enzyme HDAC with the IC<sub>50</sub> of 20.78±2.86 mM while compound <strong>2</strong> exhibited no effect on HDAC at 25 mM.</p> <p><strong>Keywords. </strong><em>Viburnum sambucinum</em>, Caprifoliaceae, hupehenol D (<strong>1</strong>), 12<em>β</em>-hydoxy-3,15-dioxo-20,21,22-23,24,25,26,27-octanordammanrane (<strong>2</strong>), 3D cytotoxic, HDAC inhibitory activity.</p>}, number={6}, journal={Vietnam Journal of Chemistry}, author={Tra, Nguyen Thanh and Thu Ha, Nguyen Thi and Cham, Ba Thi and Tu Anh, Le Thi and Thao, Do Thi and Nga, Nguyen Thi and Mai Huong, Doan Thi and Cuong, Pham Van}, year={2017}, month={Dec.}, pages={724} }