• Hoàng Thị Kim Dung Institute of Chemical Technology – VAST, 1 Mac Dinh Chi Str., Dist.1, Hochiminh city, Vietnam Graduate University of Science and Technology – VAST, 18 Hoang Quoc Viet Str., Cau Giay Dist., Hanoi, Vietnam https://orcid.org/0000-0002-9369-8051
  • Hoang-Phuc Nguyen Institute of Chemical Technology – VAST, 1 Mac Dinh Chi Str., Dist.1, Hochiminh city, Vietnam Ton Duc Thang University, 19 Nguyen Huu Tho, Dist. 7, Hochiminh city, Vietnam
  • Thi-Kim-Chi Huynh Institute of Chemical Technology – VAST, 1 Mac Dinh Chi Str., Dist.1, Hochiminh city, Vietnam Graduate University of Science and Technology – VAST, 18 Hoang Quoc Viet Str., Cau Giay Dist., Hanoi, Vietnam




flavones, flavanones, achetylcholinesterase, structure-activity relationship, molecular docking


Discovering and developing drugs to treat Alzheimer's disease (AD) have been a crucial target for many decades. According to a large number of later studies, acetylcholinesterase (AChE) plays an important role in AD treatment. On the other hand, flavonoids are natural compounds that possessed a wide variety of bioactivities, including the inhibitory activity on AChE. In this study, we reported the structure and activity relationship of flavone and flavanone derivatives that semi-synthesized and synthesized from flower buds of Styphnolobium japonicum (Leguminosae) and citrus peels against AChE. The results showed that the introducing of the new functional groups that leads to increasing 3-folds better AChE inhibition of compound Q2 and Q4 than that of the original. The molecular docking study was investigated in order to illuminate the experimental results and find their binding modes.


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How to Cite

Dung, H. T. K., Nguyen, H.-P., & Huynh, T.-K.-C. (2021). FLAVONES AND FLAVANONES AS ACHETYLCHOLINESTERASE INHIBITORS: THE STRUCTURE-ACTIVITY RELATIONSHIP AND MOLECULAR DOCKING STUDIES. Vietnam Journal of Science and Technology, 59(4), 441. https://doi.org/10.15625/2525-2518/59/4/15487



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