Nghiên cứu tổng hợp gefitinib làm nguyên liệu bào chế thuốc điều trị ung thư phổi


Authors

  • Vương Văn Trường
  • Hoàng Như Kha
  • Đỗ Thị Thùy Trang
  • Phạm Duy Nam
  • Nguyễn Văn Ngọc
  • Trần Đức Quân
  • Dương Đức Hoàng
DOI: https://doi.org/10.15625/0866-7144.2015-00156

Keywords:

Gefitinib, isovanillin, lung cancer

Abstract

Gefitinib is an anilinoquinazoline which is useful in the treatment of a certain type of lung cancer (non-small cell lung cancer - NSCLC) that has not responded to chemotherapy. In this paper, we report results of synthesis of gefitinib and intermediates. Structure of gefitinib and its intermediates was confirmed by spectroscopic methods such as IR, 1H NMR, 13C NMR and MS.

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Published

31-08-2015

How to Cite

Trường, V. V., Kha, H. N., Thùy Trang, Đỗ T., Nam, P. D., Ngọc, N. V., Quân, T. Đức, & Hoàng, D. Đức. (2015). Nghiên cứu tổng hợp gefitinib làm nguyên liệu bào chế thuốc điều trị ung thư phổi. Vietnam Journal of Chemistry, 53(4), 425–431. https://doi.org/10.15625/0866-7144.2015-00156

Issue

Vol. 53 No. 4 (2015)

Section

Articles