Synthesis of antiulcer drug esomeprazole.


Authors

  • Tran Huu Giap Nhà xuất bản Khoa học Tự nhiên và Công nghệ
  • To Hai Tung
  • Van Thi My Hue
  • Cao Thi Hue
  • Nguyen Thi Minh Hang
  • Chau Van Minh
  • Le Nguyen Thanh
DOI: https://doi.org/10.15625/0866-7144.2015-2e-011

Keywords:

Peptic Ulcer, Proton Pump Inhibitor, Omeprazole, Esomeprazole

Abstract

Esomeprazole (Nexium®), the (S)-isomer of Omeprazole, is the first proton-pump inhibitor developed as a single isomer for the treatment of acid-related diseases. It is used for the treatment of peptic ulcers, gastroesophagal reflux disease, and erosive esophagitis. Herein, we report our synthetic study of esomeprazole sodium salt from the starting    2-mercapto-5-methoxybenzimidazole and 2-(chloromethyl)-4-methoxy-3,5-dimethylpyridine hydrochloride reagents. The Esomeprazole sodium salt was obtained from enantioselectivesulfoxidation reaction in moderate yield with high enantioselectivity.

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Published

21-05-2015

How to Cite

Giap, T. H., Tung, T. H., My Hue, V. T., Hue, C. T., Minh Hang, N. T., Minh, C. V., & Thanh, L. N. (2015). Synthesis of antiulcer drug esomeprazole. Vietnam Journal of Chemistry, 53(2e), 48–51. https://doi.org/10.15625/0866-7144.2015-2e-011

Issue

Vol. 53 No. 2e (2015)

Section

Articles