Các hợp chất thứ cấp từ chủng xạ khuẩn biển Micromonospora sp. (G043)


Authors

  • Cao Đức Tuấn
  • Trần Văn Hiệu
  • Đoàn Thị Mai Hương
  • Vũ Thị Quyên
  • Lê Thị Hồng Minh
  • Brian Murphy
  • Châu Văn Minh
  • Phạm Văn Cường
DOI: https://doi.org/10.15625/0866-7144.2016-00368

Keywords:

Micromonospora sp. (G043 strain), marine microorganism, cyclodipeptide, antimicrobial activity.

Abstract

Analysis of an antimicrobial extract prepared from culture broth of the marine-derived actinomycete Micromonospora sp. (strain G043) led to the isolation of 9 secondary metabolites and identified as Cyclo-(Pro-Leu) (1), Cyclo-(Pro-Val) (2), Cyclo-(Pro-Trp) (3), Cyclo-(Pro-Phe) (4), Cyclo-(Pro-Tyr) (5), and Cyclo-(Leu-Tyr) (6), 2-phenylacetic acid (7), N-(4-hydroxyphenylethyl)acetamide (8), bis(2-ethylhexyl) adipate (9). The structures of 1-9 were determined by analyses of MS and 2D NMR data. All compounds were evaluated for their antimicrobial activity against a panel of clinically significant microorganisms. Compounds 3, 6 and 7 inhibited Escherichia coli with a MIC value of 128, 32 and 32 µg/ml, respectively.

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Published

30-10-2016

How to Cite

Tuấn, C. Đức, Hiệu, T. V., Mai Hương, Đoàn T., Quyên, V. T., Hồng Minh, L. T., Murphy, B., Minh, C. V., & Cường, P. V. (2016). Các hợp chất thứ cấp từ chủng xạ khuẩn biển Micromonospora sp. (G043). Vietnam Journal of Chemistry, 54(5), 581. https://doi.org/10.15625/0866-7144.2016-00368

Issue

Vol. 54 No. 5 (2016)

Section

Articles