Nghiên cứu điều chế hydrogel nhạy nhiệt trên cơ sở copolyme ghép chitosan-pluronic F127 định hướng ứng dụng trong chữa lành vết thương


Authors

  • Nguyễn Thị Bích Trâm
  • Đặng Thị Lệ Hằng
  • Lê Thị Thu Thắm
  • Nguyễn Đại Hải
  • Nguyễn Cửu Khoa
  • Trần Ngọc Quyển
DOI: https://doi.org/10.15625/0866-7144.2016-00372

Keywords:

Thermosensitive hydrogel, chitosan, pluronic, wound healing.

Abstract

In recent years, injectable chitosan-based hydrogels have been widely studied towards biomedical applications because of their potential performance in drug/cell delivery and tissue regeneration. In this study, a temperature-sensitive bio-hydrogel based on chitosan and pluronic was synthesized. The structure of copolymer was characterized by IR and 1H-NMR spectroscopy. The sol-gel phase transition behavior of hydrogel was rheology method. The in vitro experiments showed that, the solutions of chitosan-pluronic F127 were changed to gel stage to gel stage when the temperature increased from 25 oC to 40 oC. The result is a prerequisite for the interesting studies of this complex hydrogel.

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Published

30-10-2016

How to Cite

Bích Trâm, N. T., Lệ Hằng, Đặng T., Thu Thắm, L. T., Hải, N. Đại, Khoa, N. C., & Quyển, T. N. (2016). Nghiên cứu điều chế hydrogel nhạy nhiệt trên cơ sở copolyme ghép chitosan-pluronic F127 định hướng ứng dụng trong chữa lành vết thương. Vietnam Journal of Chemistry, 54(5), 603. https://doi.org/10.15625/0866-7144.2016-00372

Issue

Vol. 54 No. 5 (2016)

Section

Articles