Crystallization technology: selective polymorphism of L-glutamic acid in anti-solvent crystallization


Authors

  • Nguyen Thi Ngoc Phuong
  • Khuu Chau Quang
  • Nguyen Dinh Tuyet
  • Tran Thi Dieu Thuy
  • Trinh Thi Thanh Huyen
  • Le Thi Hong Nhan
  • Phan Thanh Thao
  • Nguyen Anh Tuan
DOI: https://doi.org/10.15625/7626

Keywords:

Crystallization, polymorphism, phase transformation, anti-solvent crystallization

Abstract

The selective polymorphism of L-glutamic acid was firstly investigated in anti-solvent crystallization with a high productivity. When the ratio of feed solution and anti-solvent was varied from 90:10 to 80:20, the pure metastable α-form crystal was crystallized at 300C, 18.5g/l feed concentration and 360rpm of agitation speed. However, when the ratio of feed solution and anti-solvent was varied from 70:30 to 40:60, the mixture of α-form and b-form crystal product was precipitated. Further decreasing the ratio of feed solution and anti-solvent from 30:70 to 10:90, the only pure stable b-form crystal was crystallized. The results indicated that the supersaturation determined by the ratio of feed solution and anti-solvent was a key factor to impact on the nucleation process, in which the nucleation of α-form and b-form was favorably crystallized at a low and high supersaturation, respectively, which resulted in the selective polymorphism of L-glutamic acid in the anti-solvent crystallization.

Keywords. Crystallization, polymorphism, phase transformation, anti-solvent crystallization.

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Published

01-12-2015

How to Cite

Ngoc Phuong, N. T., Quang, K. C., Tuyet, N. D., Dieu Thuy, T. T., Thanh Huyen, T. T., Hong Nhan, L. T., Thao, P. T., & Tuan, N. A. (2015). Crystallization technology: selective polymorphism of L-glutamic acid in anti-solvent crystallization. Vietnam Journal of Chemistry, 53(5), 600. https://doi.org/10.15625/7626

Issue

Vol. 53 No. 5 (2015)

Section

Articles